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MLL基因重排成人急性髓系白血病的特征和预后分析 - PMC

混合谱系白血病（mixed lineage leukemia，MLL）基因定位于11号染色体长臂2区3带（11q23），由Ziemin-van der Poel等 [1] 于1991年首次报道。. MLL基因重排是造血系

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2019年9月6日  2019年9月4日，国际学术期刊《自然》（Nature）在线发表了上海精准医学研究院黄晶课题组的最新研究成果“Structural basis of nucleosome recognition and modification by MLL methyltransferases”，

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MLL portal for diagnostic reports: here you can find your

The feedback from previous portal users has also been extremely positive. In the MLL portal for diagnostic reports, we make all diagnostic reports from your clinic/practice (since 2017) available to you digitally and up-to-date to the minute. New or older reports can be opened and downloaded with just a few clicks – anytime and anywhere.

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MLL基因重排成人急性髓系白血病的特征和预后分析 - PMC

MLL基因重排有易位、部分串联重复（PTD）、缺失、插入和倒置几种形式，其中易位最常见[3]。易位形成的MLL融合蛋白引起转录调控异常及诱导MLL下游的目的基因如HOX、EPHA7、MEIS、PBX等异常表达，从而影响造血分化，导致白血病等的发生[4]。

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